Intron evolution within 23 organisms

Overview

This site contains supplementary information to our analysis of alvelan intron evolution (Csuros, Rogozin, Koonin Extremely intron-rich genes in the alveolate ancestors inferred with a flexible likelihood approach, submitted). For every orthologous gene family in the data set, the inferred intron histories are shown, along with multiple alignments and gene structure annotation.

Phylogeny

phylogeny

Gene families

  1. KOG0004 (3 sites) Ubiquitin/40S ribosomal protein S27a fusion
  2. KOG0012 (24 sites) DNA damage inducible protein
  3. KOG0050 (27 sites) mRNA splicing protein CDC5 (Myb superfamily)
  4. KOG0073 (8 sites) GTP-binding ADP-ribosylation factor-like protein ARL2
  5. KOG0077 (11 sites) Vesicle coat complex COPII, GTPase subunit SAR1
  6. KOG0090 (7 sites) Signal recognition particle receptor, beta subunit (small G protein superfamily)
  7. KOG0094 (12 sites) GTPase Rab6/YPT6/Ryh1, small G protein superfamily
  8. KOG0103 (31 sites) Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily
  9. KOG0104 (44 sites) Molecular chaperones GRP170/SIL1, HSP70 superfamily
  10. KOG0114 (5 sites) Predicted RNA-binding protein (RRM superfamily)
  11. KOG0120 (18 sites) Splicing factor U2AF, large subunit (RRM superfamily)
  12. KOG0121 (8 sites) Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily)
  13. KOG0122 (13 sites) Translation initiation factor 3, subunit g (eIF-3g)
  14. KOG0126 (7 sites) Predicted RNA-binding protein (RRM superfamily)
  15. KOG0130 (4 sites) RNA-binding protein RBM8/Tsunagi (RRM superfamily)
  16. KOG0131 (14 sites) Splicing factor 3b, subunit 4
  17. KOG0147 (20 sites) Transcriptional coactivator CAPER (RRM superfamily)
  18. KOG0151 (24 sites) Predicted splicing regulator, contains RRM, SWAP and RPR domains
  19. KOG0174 (15 sites) 20S proteasome, regulatory subunit beta type PSMB6/PSMB9/PRE3
  20. KOG0176 (14 sites) 20S proteasome, regulatory subunit alpha type PSMA5/PUP2
  21. KOG0177 (15 sites) 20S proteasome, regulatory subunit beta type PSMB2/PRE1
  22. KOG0181 (21 sites) 20S proteasome, regulatory subunit alpha type PSMA2/PRE8
  23. KOG0185 (10 sites) 20S proteasome, regulatory subunit beta type PSMB4/PRE4
  24. KOG0214 (23 sites) RNA polymerase II, second largest subunit
  25. KOG0215 (92 sites) RNA polymerase III, second largest subunit
  26. KOG0216 (57 sites) RNA polymerase I, second largest subunit
  27. KOG0226 (2 sites) RNA-binding proteins
  28. KOG0227 (13 sites) Splicing factor 3a, subunit 2
  29. KOG0260 (46 sites) RNA polymerase II, large subunit
  30. KOG0261 (56 sites) RNA polymerase III, large subunit
  31. KOG0262 (54 sites) RNA polymerase I, large subunit
  32. KOG0263 (12 sites) Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA)
  33. KOG0268 (25 sites) Sof1-like rRNA processing protein (contains WD40 repeats)
  34. KOG0270 (14 sites) WD40 repeat-containing protein
  35. KOG0276 (50 sites) Vesicle coat complex COPI, beta' subunit
  36. KOG0284 (19 sites) Polyadenylation factor I complex, subunit PFS2
  37. KOG0285 (26 sites) Pleiotropic regulator 1
  38. KOG0292 (44 sites) Vesicle coat complex COPI, alpha subunit
  39. KOG0293 (4 sites) WD40 repeat-containing protein
  40. KOG0301 (25 sites) Phospholipase A2-activating protein (contains WD40 repeats)
  41. KOG0302 (18 sites) Ribosome Assembly protein
  42. KOG0307 (37 sites) Vesicle coat complex COPII, subunit SEC31
  43. KOG0316 (17 sites) Conserved WD40 repeat-containing protein
  44. KOG0319 (31 sites) WD40-repeat-containing subunit of the 18S rRNA processing complex
  45. KOG0326 (27 sites) ATP-dependent RNA helicase
  46. KOG0328 (35 sites) Predicted ATP-dependent RNA helicase FAL1, involved in rRNA maturation, DEAD-box superfamily
  47. KOG0334 (38 sites) RNA helicase
  48. KOG0337 (16 sites) ATP-dependent RNA helicase
  49. KOG0338 (40 sites) ATP-dependent RNA helicase
  50. KOG0341 (31 sites) DEAD-box protein abstrakt
  51. KOG0343 (12 sites) RNA Helicase
  52. KOG0345 (33 sites) ATP-dependent RNA helicase
  53. KOG0347 (9 sites) RNA helicase
  54. KOG0355 (41 sites) DNA topoisomerase type II
  55. KOG0358 (28 sites) Chaperonin complex component, TCP-1 delta subunit (CCT4)
  56. KOG0362 (36 sites) Chaperonin complex component, TCP-1 theta subunit (CCT8)
  57. KOG0365 (24 sites) Beta subunit of farnesyltransferase
  58. KOG0366 (20 sites) Protein geranylgeranyltransferase type II, beta subunit
  59. KOG0370 (15 sites) Multifunctional pyrimidine synthesis protein CAD (includes carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase)
  60. KOG0378 (13 sites) 40S ribosomal protein S4
  61. KOG0402 (5 sites) 60S ribosomal protein L37
  62. KOG0411 (9 sites) Uncharacterized membrane protein
  63. KOG0414 (42 sites) Chromosome condensation complex Condensin, subunit D2
  64. KOG0415 (15 sites) Predicted peptidyl prolyl cis-trans isomerase
  65. KOG0416 (4 sites) Ubiquitin-protein ligase
  66. KOG0418 (17 sites) Ubiquitin-protein ligase
  67. KOG0424 (11 sites) Ubiquitin-protein ligase
  68. KOG0425 (2 sites) Ubiquitin-protein ligase
  69. KOG0434 (38 sites) Isoleucyl-tRNA synthetase
  70. KOG0437 (35 sites) Leucyl-tRNA synthetase
  71. KOG0442 (10 sites) Structure-specific endonuclease ERCC1-XPF, catalytic component XPF/ERCC4
  72. KOG0458 (15 sites) Elongation factor 1 alpha
  73. KOG0459 (29 sites) Polypeptide release factor 3
  74. KOG0468 (52 sites) U5 snRNP-specific protein
  75. KOG0477 (43 sites) DNA replication licensing factor, MCM2 component
  76. KOG0478 (34 sites) DNA replication licensing factor, MCM4 component
  77. KOG0481 (42 sites) DNA replication licensing factor, MCM5 component
  78. KOG0495 (41 sites) HAT repeat protein
  79. KOG0525 (29 sites) Branched chain alpha-keto acid dehydrogenase E1, beta subunit
  80. KOG0558 (7 sites) Dihydrolipoamide transacylase (alpha-keto acid dehydrogenase E2 subunit)
  81. KOG0559 (26 sites) Dihydrolipoamide succinyltransferase (2-oxoglutarate dehydrogenase, E2 subunit)
  82. KOG0643 (22 sites) Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1)
  83. KOG0652 (35 sites) 26S proteasome regulatory complex, ATPase RPT5
  84. KOG0670 (8 sites) U4/U6-associated splicing factor PRP4
  85. KOG0672 (7 sites) Halotolerance protein HAL3 (contains flavoprotein domain)
  86. KOG0673 (22 sites) Thymidylate synthase
  87. KOG0688 (23 sites) Peptide chain release factor 1 (eRF1)
  88. KOG0706 (9 sites) Predicted GTPase-activating protein
  89. KOG0711 (20 sites) Polyprenyl synthetase
  90. KOG0726 (26 sites) 26S proteasome regulatory complex, ATPase RPT2
  91. KOG0728 (25 sites) 26S proteasome regulatory complex, ATPase RPT6
  92. KOG0729 (31 sites) 26S proteasome regulatory complex, ATPase RPT1
  93. KOG0733 (19 sites) Nuclear AAA ATPase (VCP subfamily)
  94. KOG0746 (21 sites) 60S ribosomal protein L3 and related proteins
  95. KOG0760 (13 sites) Mitochondrial carrier protein MRS3/4
  96. KOG0772 (23 sites) Uncharacterized conserved protein, contains WD40 repeat
  97. KOG0781 (21 sites) Signal recognition particle receptor, alpha subunit
  98. KOG0803 (2 sites) Predicted E3 ubiquitin ligase
  99. KOG0820 (21 sites) Ribosomal RNA adenine dimethylase
  100. KOG0822 (25 sites) Protein kinase inhibitor
  101. KOG0862 (1 site) Synaptobrevin/VAMP-like protein SEC22
  102. KOG0882 (46 sites) Cyclophilin-related peptidyl-prolyl cis-trans isomerase
  103. KOG0883 (22 sites) Cyclophilin type, U box-containing peptidyl-prolyl cis-trans isomerase
  104. KOG0885 (14 sites) Peptidyl-prolyl cis-trans isomerase
  105. KOG0890 (7 sites) Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination
  106. KOG0900 (5 sites) 40S ribosomal protein S20
  107. KOG0911 (9 sites) Glutaredoxin-related protein
  108. KOG0924 (23 sites) mRNA splicing factor ATP-dependent RNA helicase
  109. KOG0926 (50 sites) DEAH-box RNA helicase
  110. KOG0939 (18 sites) E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein
  111. KOG0953 (10 sites) Mitochondrial RNA helicase SUV3, DEAD-box superfamily
  112. KOG0962 (5 sites) DNA repair protein RAD50, ABC-type ATPase/SMC superfamily
  113. KOG0964 (77 sites) Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin, subunit SMC3)
  114. KOG0967 (38 sites) ATP-dependent DNA ligase I
  115. KOG0969 (72 sites) DNA polymerase delta, catalytic subunit
  116. KOG0979 (25 sites) Structural maintenance of chromosome protein SMC5/Spr18, SMC superfamily
  117. KOG0981 (25 sites) DNA topoisomerase I
  118. KOG0985 (72 sites) Vesicle coat protein clathrin, heavy chain
  119. KOG0997 (16 sites) Uncharacterized conserved protein Sand
  120. KOG1004 (9 sites) Exosomal 3'-5' exoribonuclease complex subunit Rrp40
  121. KOG1007 (3 sites) WD repeat protein TSSC1, WD repeat superfamily
  122. KOG1035 (3 sites) eIF-2alpha kinase GCN2
  123. KOG1038 (28 sites) Mitochondrial/chloroplast DNA-directed RNA polymerase RPO41, provides primers for DNA replication-initiation
  124. KOG1058 (49 sites) Vesicle coat complex COPI, beta subunit
  125. KOG1059 (5 sites) Vesicle coat complex AP-3, delta subunit
  126. KOG1060 (8 sites) Vesicle coat complex AP-3, beta subunit
  127. KOG1073 (4 sites) Uncharacterized mRNA-associated protein RAP55
  128. KOG1078 (37 sites) Vesicle coat complex COPI, gamma subunit
  129. KOG1080 (6 sites) Histone H3 (Lys4) methyltransferase complex, subunit SET1 and related methyltransferases
  130. KOG1105 (10 sites) Transcription elongation factor TFIIS/Cofactor of enhancer-binding protein Sp1
  131. KOG1122 (31 sites) tRNA and rRNA cytosine-C5-methylase (nucleolar protein NOL1/NOP2)
  132. KOG1128 (26 sites) Uncharacterized conserved protein, contains TPR repeats
  133. KOG1147 (26 sites) Glutamyl-tRNA synthetase
  134. KOG1242 (16 sites) Protein containing adaptin N-terminal region
  135. KOG1272 (23 sites) WD40-repeat-containing subunit of the 18S rRNA processing complex
  136. KOG1274 (15 sites) WD40 repeat protein
  137. KOG1297 (8 sites) Uncharacterized conserved protein
  138. KOG1302 (27 sites) Vacuolar sorting protein VPS33/slp1 (Sec1 family)
  139. KOG1349 (20 sites) Gpi-anchor transamidase
  140. KOG1352 (47 sites) Vacuolar H+-ATPase V1 sector, subunit A
  141. KOG1355 (21 sites) Adenylosuccinate synthase
  142. KOG1370 (27 sites) S-adenosylhomocysteine hydrolase
  143. KOG1373 (28 sites) Transport protein Sec61, alpha subunit
  144. KOG1374 (31 sites) Gamma tubulin
  145. KOG1380 (13 sites) Heme A farnesyltransferase
  146. KOG1381 (19 sites) Para-hydroxybenzoate-polyprenyl transferase
  147. KOG1396 (5 sites) Uncharacterized conserved protein
  148. KOG1439 (31 sites) RAB proteins geranylgeranyltransferase component A (RAB escort protein)
  149. KOG1465 (17 sites) Translation initiation factor 2B, beta subunit (eIF-2Bbeta/GCD7)
  150. KOG1490 (34 sites) GTP-binding protein CRFG/NOG1 (ODN superfamily)
  151. KOG1507 (17 sites) Nucleosome assembly protein NAP-1
  152. KOG1514 (17 sites) Origin recognition complex, subunit 1, and related proteins
  153. KOG1522 (8 sites) RNA polymerase II, subunit POLR2C/RPB3
  154. KOG1532 (18 sites) GTPase XAB1, interacts with DNA repair protein XPA
  155. KOG1533 (10 sites) Predicted GTPase
  156. KOG1548 (7 sites) Transcription elongation factor TAT-SF1
  157. KOG1586 (15 sites) Protein required for fusion of vesicles in vesicular transport, alpha-SNAP
  158. KOG1614 (10 sites) Exosomal 3'-5' exoribonuclease complex, subunit Rrp45
  159. KOG1625 (13 sites) DNA polymerase alpha-primase complex, polymerase-associated subunit B
  160. KOG1627 (8 sites) Translation elongation factor EF-1 gamma
  161. KOG1643 (9 sites) Triosephosphate isomerase
  162. KOG1644 (8 sites) U2-associated snRNP A' protein
  163. KOG1646 (15 sites) 40S ribosomal protein S6
  164. KOG1652 (6 sites) Mitochondrial import inner membrane translocase, subunit TIM17
  165. KOG1655 (14 sites) Protein involved in vacuolar protein sorting
  166. KOG1664 (10 sites) Vacuolar H+-ATPase V1 sector, subunit E
  167. KOG1678 (13 sites) 60s ribosomal protein L15
  168. KOG1679 (9 sites) Enoyl-CoA hydratase
  169. KOG1684 (20 sites) Enoyl-CoA hydratase
  170. KOG1692 (4 sites) Putative cargo transport protein EMP24 (p24 protein family)
  171. KOG1696 (11 sites) 60s ribosomal protein L19
  172. KOG1714 (12 sites) 60s ribosomal protein L18
  173. KOG1728 (9 sites) 40S ribosomal protein S11
  174. KOG1730 (8 sites) Thioredoxin-like protein
  175. KOG1763 (23 sites) Uncharacterized conserved protein, contains CCCH-type Zn-finger
  176. KOG1779 (6 sites) 40s ribosomal protein S27
  177. KOG1781 (4 sites) Small Nuclear ribonucleoprotein splicing factor
  178. KOG1793 (19 sites) Uncharacterized conserved protein
  179. KOG1798 (73 sites) DNA polymerase epsilon, catalytic subunit A
  180. KOG1806 (21 sites) DEAD box containing helicases
  181. KOG1820 (35 sites) Microtubule-associated protein
  182. KOG1872 (30 sites) Ubiquitin-specific protease
  183. KOG1874 (37 sites) KEKE-like motif-containing transcription regulator (Rlr1)/suppressor of sin4
  184. KOG1888 (8 sites) Putative phosphoinositide phosphatase
  185. KOG1896 (28 sites) mRNA cleavage and polyadenylation factor II complex, subunit CFT1 (CPSF subunit)
  186. KOG1898 (35 sites) Splicing factor 3b, subunit 3
  187. KOG1915 (40 sites) Cell cycle control protein (crooked neck)
  188. KOG1943 (12 sites) Beta-tubulin folding cofactor D
  189. KOG1961 (31 sites) Vacuolar sorting protein VPS52/suppressor of actin Sac2
  190. KOG1969 (15 sites) DNA replication checkpoint protein CHL12/CTF18
  191. KOG1975 (13 sites) mRNA cap methyltransferase
  192. KOG1984 (32 sites) Vesicle coat complex COPII, subunit SFB3
  193. KOG1985 (46 sites) Vesicle coat complex COPII, subunit SEC24/subunit SFB2
  194. KOG1996 (3 sites) mRNA splicing factor
  195. KOG2001 (24 sites) Gamma-tubulin complex, DGRIP84/SPC97 component
  196. KOG2002 (18 sites) TPR-containing nuclear phosphoprotein that regulates K(+) uptake
  197. KOG2005 (55 sites) 26S proteasome regulatory complex, subunit RPN1/PSMD2
  198. KOG2007 (24 sites) Cysteinyl-tRNA synthetase
  199. KOG2015 (21 sites) NEDD8-activating complex, catalytic component UBA3
  200. KOG2017 (16 sites) Molybdopterin synthase sulfurylase
  201. KOG2023 (45 sites) Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily)
  202. KOG2030 (26 sites) Predicted RNA-binding protein
  203. KOG2036 (58 sites) Predicted P-loop ATPase fused to an acetyltransferase
  204. KOG2042 (38 sites) Ubiquitin fusion degradation protein-2
  205. KOG2048 (1 site) WD40 repeat protein
  206. KOG2050 (25 sites) Puf family RNA-binding protein
  207. KOG2051 (2 sites) Nonsense-mediated mRNA decay 2 protein
  208. KOG2062 (48 sites) 26S proteasome regulatory complex, subunit RPN2/PSMD1
  209. KOG2067 (14 sites) Mitochondrial processing peptidase, alpha subunit
  210. KOG2068 (9 sites) MOT2 transcription factor
  211. KOG2072 (23 sites) Translation initiation factor 3, subunit a (eIF-3a)
  212. KOG2086 (12 sites) Protein tyrosine phosphatase SHP1/Cofactor for p97 ATPase-mediated vesicle membrane fusion
  213. KOG2090 (37 sites) Metalloendopeptidase family - mitochondrial intermediate peptidase
  214. KOG2140 (21 sites) Uncharacterized conserved protein
  215. KOG2141 (11 sites) Protein involved in high osmolarity signaling pathway
  216. KOG2145 (22 sites) Cytoplasmic tryptophanyl-tRNA synthetase
  217. KOG2146 (6 sites) Splicing coactivator SRm160/300, subunit SRm160 (contains PWI domain)
  218. KOG2159 (21 sites) tRNA nucleotidyltransferase/poly(A) polymerase
  219. KOG2180 (41 sites) Late Golgi protein sorting complex, subunit Vps53
  220. KOG2217 (4 sites) U4/U6.U5 snRNP associated protein
  221. KOG2241 (13 sites) tRNA-binding protein
  222. KOG2270 (10 sites) Serine/threonine protein kinase involved in cell cycle control
  223. KOG2295 (12 sites) C2H2 Zn-finger protein
  224. KOG2298 (33 sites) Glycyl-tRNA synthetase and related class II tRNA synthetase
  225. KOG2299 (19 sites) Ribonuclease HI
  226. KOG2310 (21 sites) DNA repair exonuclease MRE11
  227. KOG2311 (39 sites) NAD/FAD-utilizing protein possibly involved in translation
  228. KOG2315 (18 sites) Predicted translation initiation factor related to eIF-3a
  229. KOG2316 (10 sites) Predicted ATPase (PP-loop superfamily)
  230. KOG2318 (23 sites) Uncharacterized conserved protein
  231. KOG2321 (25 sites) WD40 repeat protein
  232. KOG2340 (23 sites) Uncharacterized conserved protein
  233. KOG2370 (13 sites) Cactin
  234. KOG2379 (17 sites) Endonuclease MUS81
  235. KOG2385 (9 sites) Uncharacterized conserved protein
  236. KOG2387 (35 sites) CTP synthase (UTP-ammonia lyase)
  237. KOG2388 (3 sites) UDP-N-acetylglucosamine pyrophosphorylase
  238. KOG2391 (12 sites) Vacuolar sorting protein/ubiquitin receptor VPS23
  239. KOG2396 (26 sites) HAT (Half-A-TPR) repeat-containing protein
  240. KOG2409 (21 sites) KRR1-interacting protein involved in 40S ribosome biogenesis
  241. KOG2420 (14 sites) Phosphatidylserine decarboxylase
  242. KOG2422 (31 sites) Uncharacterized conserved protein
  243. KOG2423 (23 sites) Nucleolar GTPase
  244. KOG2434 (9 sites) RNA polymerase I transcription factor
  245. KOG2439 (10 sites) Nuclear architecture related protein
  246. KOG2441 (16 sites) mRNA splicing factor/probable chromatin binding snw family nuclear protein
  247. KOG2460 (4 sites) Signal recognition particle, subunit Srp68
  248. KOG2477 (20 sites) Uncharacterized conserved protein
  249. KOG2485 (2 sites) Conserved ATP/GTP binding protein
  250. KOG2487 (10 sites) RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4
  251. KOG2489 (20 sites) Transmembrane protein
  252. KOG2498 (6 sites) IK cytokine down-regulator of HLA class II
  253. KOG2518 (19 sites) 5'-3' exonuclease
  254. KOG2519 (34 sites) 5'-3' exonuclease
  255. KOG2535 (26 sites) RNA polymerase II elongator complex, subunit ELP3/histone acetyltransferase
  256. KOG2540 (20 sites) Cytochrome oxidase assembly factor COX11
  257. KOG2545 (10 sites) Conserved membrane protein
  258. KOG2550 (30 sites) IMP dehydrogenase/GMP reductase
  259. KOG2553 (14 sites) Pseudouridylate synthase
  260. KOG2554 (12 sites) Pseudouridylate synthase
  261. KOG2572 (22 sites) Ribosome biogenesis protein - Nop58p/Nop5p
  262. KOG2580 (8 sites) Mitochondrial import inner membrane translocase, subunit TIM44
  263. KOG2581 (25 sites) 26S proteasome regulatory complex, subunit RPN3/PSMD3
  264. KOG2600 (19 sites) U3 small nucleolar ribonucleoprotein (snoRNP) subunit - Mpp10p
  265. KOG2627 (11 sites) Nuclear protein ES2
  266. KOG2628 (2 sites) Farnesyl cysteine-carboxyl methyltransferase
  267. KOG2654 (10 sites) Uncharacterized conserved protein
  268. KOG2671 (24 sites) Putative RNA methylase
  269. KOG2675 (3 sites) Adenylate cyclase-associated protein (CAP/Srv2p)
  270. KOG2691 (6 sites) RNA polymerase II subunit 9
  271. KOG2708 (17 sites) Predicted metalloprotease with chaperone activity (RNAse H/HSP70 fold)
  272. KOG2730 (2 sites) Methylase
  273. KOG2734 (15 sites) Uncharacterized conserved protein
  274. KOG2738 (29 sites) Putative methionine aminopeptidase
  275. KOG2749 (20 sites) mRNA cleavage and polyadenylation factor IA/II complex, subunit CLP1
  276. KOG2758 (14 sites) Translation initiation factor 3, subunit e (eIF-3e)
  277. KOG2760 (7 sites) Vacuolar sorting protein VPS36
  278. KOG2767 (8 sites) Translation initiation factor 5 (eIF-5)
  279. KOG2768 (8 sites) Translation initiation factor 2, beta subunit (eIF-2beta)
  280. KOG2770 (18 sites) Aminomethyl transferase
  281. KOG2776 (18 sites) Metallopeptidase
  282. KOG2779 (21 sites) N-myristoyl transferase
  283. KOG2788 (14 sites) Glycosyltransferase
  284. KOG2792 (14 sites) Putative cytochrome C oxidase assembly protein
  285. KOG2830 (9 sites) Protein phosphatase 2A-associated protein
  286. KOG2832 (16 sites) TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation)
  287. KOG2840 (14 sites) Uncharacterized conserved protein with similarity to predicted ATPase of the PP-loop superfamily
  288. KOG2851 (13 sites) Eukaryotic-type DNA primase, catalytic (small) subunit
  289. KOG2863 (11 sites) RNA lariat debranching enzyme
  290. KOG2868 (8 sites) Decapping enzyme complex component DCP1
  291. KOG2869 (31 sites) Meiotic cell division protein Pelota/DOM34
  292. KOG2874 (25 sites) rRNA processing protein
  293. KOG2887 (7 sites) Membrane protein involved in ER to Golgi transport
  294. KOG2888 (7 sites) Putative RNA binding protein
  295. KOG2893 (7 sites) Zn finger protein
  296. KOG2894 (15 sites) Uncharacterized conserved protein XAP-5
  297. KOG2908 (21 sites) 26S proteasome regulatory complex, subunit RPN9/PSMD13
  298. KOG2909 (16 sites) Vacuolar H+-ATPase V1 sector, subunit C
  299. KOG2912 (12 sites) Predicted DNA methylase
  300. KOG2915 (14 sites) tRNA(1-methyladenosine) methyltransferase, subunit GCD14
  301. KOG2916 (23 sites) Translation initiation factor 2, alpha subunit (eIF-2alpha)
  302. KOG2920 (7 sites) Predicted methyltransferase
  303. KOG2923 (1 site) Uncharacterized conserved protein
  304. KOG2927 (15 sites) Membrane component of ER protein translocation complex
  305. KOG2928 (7 sites) Origin recognition complex, subunit 2
  306. KOG2937 (14 sites) Decapping enzyme complex, predicted pyrophosphatase DCP2
  307. KOG2948 (26 sites) Predicted metal-binding protein
  308. KOG2957 (23 sites) Vacuolar H+-ATPase V0 sector, subunit d
  309. KOG2963 (11 sites) RNA-binding protein required for 60S ribosomal subunit biogenesis
  310. KOG2978 (10 sites) Dolichol-phosphate mannosyltransferase
  311. KOG2983 (6 sites) Uncharacterized conserved protein
  312. KOG2990 (8 sites) C2C2-type Zn-finger protein
  313. KOG2994 (21 sites) Uracil DNA glycosylase
  314. KOG3003 (11 sites) Molecular chaperone of the GrpE family
  315. KOG3013 (12 sites) Exosomal 3'-5' exoribonuclease complex, subunit Rrp4
  316. KOG3026 (9 sites) Splicing factor SPF30
  317. KOG3034 (3 sites) Isoamyl acetate-hydrolyzing esterase and related enzymes
  318. KOG3036 (15 sites) Protein involved in cell differentiation/sexual development
  319. KOG3052 (19 sites) Cytochrome c1
  320. KOG3063 (10 sites) Membrane coat complex Retromer, subunit VPS26
  321. KOG3064 (17 sites) RNA-binding nuclear protein (MAK16) containing a distinct C4 Zn-finger
  322. KOG3068 (11 sites) mRNA splicing factor
  323. KOG3096 (6 sites) Spliceosome-associated coiled-coil protein
  324. KOG3102 (1 site) Uncharacterized conserved protein
  325. KOG3104 (9 sites) Mod5 protein sorting/negative effector of RNA Pol III synthesis
  326. KOG3110 (9 sites) Riboflavin kinase
  327. KOG3113 (10 sites) Uncharacterized conserved protein
  328. KOG3123 (11 sites) Diphthine synthase
  329. KOG3129 (6 sites) 26S proteasome regulatory complex, subunit PSMD9
  330. KOG3152 (8 sites) TBP-binding protein, activator of basal transcription (contains rrm motif)
  331. KOG3153 (1 site) Thiamine pyrophosphokinase
  332. KOG3154 (11 sites) Uncharacterized conserved protein
  333. KOG3163 (18 sites) Uncharacterized conserved protein related to ribosomal protein S8E
  334. KOG3165 (7 sites) Predicted nucleic-acid-binding protein, contains PIN domain
  335. KOG3169 (3 sites) RNA polymerase II transcriptional regulation mediator
  336. KOG3170 (8 sites) Conserved phosducin-like protein
  337. KOG3172 (4 sites) Small nuclear ribonucleoprotein Sm D3
  338. KOG3181 (14 sites) 40S ribosomal protein S3
  339. KOG3198 (4 sites) Signal recognition particle, subunit Srp19
  340. KOG3206 (14 sites) Alpha-tubulin folding cofactor B
  341. KOG3214 (4 sites) Uncharacterized Zn ribbon-containing protein
  342. KOG3220 (14 sites) Similar to bacterial dephospho-CoA kinase
  343. KOG3230 (16 sites) Vacuolar assembly/sorting protein DID4
  344. KOG3252 (9 sites) Uncharacterized conserved protein
  345. KOG3262 (7 sites) H/ACA small nucleolar RNP component GAR1
  346. KOG3265 (6 sites) Histone chaperone involved in gene silencing
  347. KOG3273 (15 sites) Predicted RNA-binding protein Pno1p interacting with Nob1p and involved in 26S proteasome assembly
  348. KOG3277 (4 sites) Uncharacterized conserved protein
  349. KOG3283 (15 sites) 40S ribosomal protein S8
  350. KOG3294 (4 sites) WW domain binding protein WBP-2, contains GRAM domain
  351. KOG3296 (10 sites) Translocase of outer mitochondrial membrane complex, subunit TOM40
  352. KOG3297 (6 sites) DNA-directed RNA polymerase subunit E'
  353. KOG3298 (6 sites) DNA-directed RNA polymerase subunit E'
  354. KOG3301 (11 sites) Ribosomal protein S4
  355. KOG3302 (10 sites) TATA-box binding protein (TBP), component of TFIID and TFIIIB
  356. KOG3311 (9 sites) Ribosomal protein S18
  357. KOG3316 (2 sites) Transport protein particle (TRAPP) complex subunit
  358. KOG3325 (9 sites) Membrane coat complex Retromer, subunit VPS29/PEP11
  359. KOG3330 (4 sites) Transport protein particle (TRAPP) complex subunit
  360. KOG3335 (10 sites) Predicted coiled-coil protein
  361. KOG3339 (3 sites) Predicted glycosyltransferase
  362. KOG3342 (10 sites) Signal peptidase I
  363. KOG3373 (7 sites) Glycine cleavage system H protein (lipoate-binding)
  364. KOG3381 (4 sites) Uncharacterized conserved protein
  365. KOG3387 (8 sites) 60S ribosomal protein 15.5kD/SNU13, NHP2/L7A family (includes ribonuclease P subunit p38), involved in splicing
  366. KOG3401 (4 sites) 60S ribosomal protein L26
  367. KOG3405 (5 sites) RNA polymerase subunit K
  368. KOG3411 (8 sites) 40S ribosomal protein S19
  369. KOG3418 (7 sites) 60S ribosomal protein L27
  370. KOG3432 (7 sites) Vacuolar H+-ATPase V1 sector, subunit F
  371. KOG3452 (4 sites) 60S ribosomal protein L36
  372. KOG3453 (7 sites) Cytochrome c
  373. KOG3460 (2 sites) Small nuclear ribonucleoprotein (snRNP) LSM3
  374. KOG3471 (22 sites) RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB2
  375. KOG3475 (9 sites) 60S ribosomal protein L37
  376. KOG3478 (4 sites) Prefoldin subunit 6, KE2 family
  377. KOG3482 (3 sites) Small nuclear ribonucleoprotein (snRNP) SMF
  378. KOG3487 (4 sites) TRAPP 20 K subunit
  379. KOG3566 (1 site) Glycosylphosphatidylinositol anchor attachment protein GAA1
  380. KOG3677 (17 sites) RNA polymerase I-associated factor - PAF67
  381. KOG3786 (19 sites) RNA polymerase II assessory factor Cdc73p
  382. KOG3800 (3 sites) Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor
  383. KOG3818 (13 sites) DNA polymerase epsilon, subunit B
  384. KOG3871 (18 sites) Cell adhesion complex protein bystin
  385. KOG3911 (1 site) Nucleolar protein NOP52/RRP1
  386. KOG3974 (19 sites) Predicted sugar kinase
  387. KOG4011 (2 sites) Transcription initiation factor TFIID, subunit TAF7
  388. KOG4098 (9 sites) Molecular chaperone Prefoldin, subunit 2
  389. KOG4392 (6 sites) RNA polymerase, subunit L
  390. KOG4426 (22 sites) Arginyl-tRNA synthetase
  391. KOG4442 (10 sites) Clathrin coat binding protein/Huntingtin interacting protein HIP1, involved in regulation of endocytosis
  392. KOG4642 (6 sites) Chaperone-dependent E3 ubiquitin protein ligase (contains TPR repeats)
  393. KOG4727 (7 sites) U1-like Zn-finger protein
  394. KOG4759 (9 sites) Ribosome recycling factor