Population and Evolutionary Genetics
University of Liege, Belgium

GIGA Graduate Courses in Genetics


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Instructors:
  
Philip Awadalla (PA) Email: philip.awadalla@umontreal.ca
Julie Hussin (JH)        Email: julie.hussin@umontreal.ca 


Textbook:  

Principles of Population Genetics by D. Hartl and A. Clark (4th edition)




Schedule and Notes
Class notes will be available the day before the lecture

WEEK 1

Monday 13/09
Notes 1 : Variation
Notes 2 : HWE

 9:00 - 12:00 :     Introduction. Mutation and the origin of genetic variation.(PA)
 2:00 -  4:30 :      Hardy-Weinberg equilibrium (PA)
                           Problems and exercices (JH)

Tuesday 14/09

 9:00 - 12:00 :     Multiple loci and linkage disequilibrium (PA)
 2:00 -  4:30 :      Problems and exercices (JH)


Wednesday 15/09
Notes 3 : Drift
Notes 4 : Inbreeding
Notes 5 : Mutation models

 9:00 - 12:00 :     Population structure: Random genetic drift, Inbreeding,
                           Effective population size (PA)
 2:00 -  4:30 :      Population structure : Population differentiation,
                           hierarchical F-statistics, genetic distance (PA)

Thursday 16/09
Notes 6 : Population models
Notes 7 : Structure

 9:00 - 12:00 :    Maintenance of genetic variation: Recurrent mutation, 
                   
      mutation-drift balance and neutral theory (PA)
 2:00 -  4:30 :     Problems and exercices (JH)


Friday 17/09
Journal Club Paper : PRUGNOLLE F. et al. 2006. Curr. Biol. 15, pp. R159-R160
Review paper on effective population size : CHARLESWORTH B. 2009. Nat. Rev. Genet. 10: 195-205

 9:00 - 12:00 :     Tutorial/Journal Club (PA and JH)



WEEK 2

Monday 20/09
Notes 8 : Coalescence - Intro
Practical1.tar.gz

 9:00 - 12:00 :     Introduction to the coalescent and genealogies (PA)
 2:00 -  4:30 :      Computer practical (JH)


Tuesday 21/09
Notes 9 : Coalescence - Recombination
Practical2.tar.gz Results

 9:00 - 12:00 :     Extending the coalescent – Recombination (PA)
 2:00 -  4:30 :      Computer practical (JH)

LINKS :
Coalescence animator

Wednesday 22/09
Notes 10 : Coalescence - Demography
Notes 11 : Coalescence - Theory
Supp. Notes : IAM

 9:00 - 12:00 :     Likelihood and Demography (PA)
 2:00 -  4:30 :      Problems and exercices (JH)


Thursday 23/09
Notes 12 : Selection

 9:00 - 12:00 :     Molecular Population Genetics of Selection Part I (PA)
 2:00 -  4:30 :      Molecular Population Genetics of Selection Part II (PA)
 

Friday 24/09
Practical3.tar.gz
SelsimCON.txt
Results

 9:00 - 12:00 :     Computer practical (JH)
 2:00 -  4:30 :      Next-generation genomics and applications to fundamental
                           and medical genomics (PA)