Nadia El-Mabrouk

Département d'informatique et de recherche opérationnelle (DIRO)

English

Page principale Recherche et publications Enseignement Laboratoire Logiciels Autres


Malgré la remarquable unité des principaux composants du monde vivant (ADN, ARN, code génétique), nous ne sommes probablement pas encore assez conscient de toute la diversité des structures génomiques existantes, ni de la diversité des modes d'évolution les générant. En plus des substitutions, insertions et délétions ponctuelles, les génomes évoluent par une multitude de mécanismes tels que réarrangements, transferts horizontaux, pertes de gènes, hybridation, duplications simples, segmentales ou même de génomes entiers. Par la comparaison de génomes, il est possible d'inférer des scénarios d'évolution pour des familles de gènes, des clusters ou des génomes entiers, et de prédire les les charactéristiques des génomes ancestraux. En plus de permettre de documenter l'histoire de l'évolution de la vie sur terre, l'inférence d'histoires évolutives permet de répondre à une multitude de questions biologiques concernant la fonction des gènes et les spécificités génétiques des espèces. Chaque problème, chaque type de mutation (ou combinaison de mutations), nécessite une modélisation spécifique et donne lieu à des développements algorithmiques, combinatoires, statistiques, mathématiques différents. C'est à ces problèmes que nous nous consacrons.



Publications

  • Reconciliation with Segmental Duplication, Transfer, Loss and Gain (preview)
    M. Delabre, Y. Anselmetti and N. El-Mabrouk
    RECOMB-CG, LNCS, Vol. 13234, pp. 124-145, Springer, 2022
  • Complexity and Algorithms for MUL-Tree Pruning
    M. Gascon, R. Dondi and N. El-Mabrouk
    IWOCA , LNCS, Vol. 12757, pp 324\--339, 2021
  • Reconstructing the history of syntenies through Super-Reconciliation (preview)
    M. Delabre, N. El-Mabrouk, K. Huber, M. Lafond, V. Moulton, E. Noutahi and M. Sautie Castellanos
    RECOMB-CG , 2018
  • A general framework for gene tree correction based on duplication-loss reconciliation (preview)
    N. El-Mabrouk and A. Ouangraoua
    WABI 2017, Algorithms in Bioinformatics, LIPIcs 88, pp. 8:1-8:14, 2017
  • Orthology Relation and Gene Tree Correction: Complexity Results (preview)
    M. Lafond and N. El-Mabrouk
    WABI 2015, Algorithms in Bioinformatics, Vol. 9289 of LNCS, pp 66-79, 2015.
  • Orthology and paralogy constraints: satisfiability and consistency
    (preview) Please take this version. The journal version is full of errors and mathematical style problems.
    Manuel Lafond and Nadia El-Mabrouk,
    BMC-Genomics, 15(Suppl 6):S12, special issue for RECOMB-CG, 2014.
  • Gene order alignment on trees with multiOrthoAlign
    (preview) Please take this version. The journal version is full of errors and mathematical style problems.
    Billel Benzaid and Nadia El-Mabrouk,
    BMC-Genomics, 15(Suppl 6):S5, special issue for RECOMB-CG, 2014.
  • Gene Tree Correction for Reconciliation and Species Tree Inference: Complexity and Algorithms
    Riccardo Dondi, Nadia El-Mabrouk, and Krister M. Swenson.
    Journal of Discrete Algorithms , Vol. 25, pp. 51 - 65, 2014
  • Gene tree correction guided by orthology
    Manuel Lafond, Magalie Semeria, Krister M. Swenson, Eric Tannier and Nadia El-Mabrouk
    BMC Bioinformatics, Vol. 14, Suppl 15, S5, 2013.
  • Gene Tree Correction for Reconciliation and Species Tree Inference
    K. M. Swenson, A. Doroftei and N. El-Mabrouk
    Algorithms for Molecular Biology, 7(1):31. doi: 10.1186/1748-7188-7-31, 2012.
  • Gene Trees and Species Trees: Irreconcilable Differences
    K. M. Swenson and N. El-Mabrouk
    BMC Bioinformatics 13 (Suppl 19): S15, 2012.
  • A Flexible Ancestral Genome Reconstruction Method based on Gapped Adjacencies
    Y. Gagnon, M. Blanchette and N. El-Mabrouk
    BMC Bioinformatics, 13 (Suppl 19): S4, 2012.
  • An Optimal Reconciliation Algorithm for Gene Trees with Polytomies (preview)
    M. Lafond, K.M. Swenson and N. El-Mabrouk
    WABI 2012, Algorithms in Bioinformatics, LNCS/LNBI 7534, pp.106-122, 2012.
  • Evolution of Genome Organization by Duplication and Loss: an Alignment Approach (preview)
    P. Holloway, K. Swenson, D. Ardell and N. El-Mabrouk
    RECOMB, LNCS/LNBI 7262, 94-112, 2012.
    RECOMB 2012 Best Paper Award
  • Analysis of Gene Order Evolution beyond Single-Copy Genes (preview)
    N. El-Mabrouk and D. Sankoff
    Methods in Molecular Biology, Vol. 855, Evolutionary Genomics: statistical and computational methods, pp. 397 - 429, Springer (Humana), 2012.
  • Evolution of orthologous tandemly arrayed gene clusters
    O. Tremblay-Savard, D. Bertrand and N. El-Mabrouk
    BMC Bioinformatics, 12(Suppl 9):S2 doi:10.1186/1471-2105-12-S9-S2, 2011.
  • Removing Noise from Gene Trees (preview)
    A. Doroftei and N. El-Mabrouk
    WABI 2011, Algorithms in Bioinformatics, LNCS/LNBI 6833, pp.76-91, 2011.
  • Reconstruction of Ancestral Genome subject to Whole Genome Duplication, Speciation, Rearrangement and Loss (preview)
    D. Bertrand, Y. Gagnon, M. Blanchette and N. El-Mabrouk
    WABI , LNCS/LNBI 6293, pp. 78- 89, 2010.
  • New perspectives on gene family evolution: losses in reconciliation and a link with supertrees. (preview)
    C. Chauve and N. El-Mabrouk.
    RECOMB, LNCS 5541, pp. 46-58, 2009.
  • The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals.
    R.S. LaRue, S.R. Jonsson, K.A.T. Silverstein, M. Lajoie, D. Bertrand, N. El-Mabrouk, I. Hotzel, V. Andresdottir, T.P.L. Smith and R.S. Harri
    BMC Molecular Biology, Vol.9, No. 104, 20 pages, 2008.
  • Inferring Ancestral Gene Orders for a Family of Tandemly Arrayed Genes.
    D. Bertrand, M. Lajoie and N. El-Mabrouk.
    Journal of Computational Biology, Vol. 15, No.8, pp 1063-1077, 2008.
  • Gene Family Evolution by Duplication, Speciation and Loss.
    C. Chauve, J.P. Doyon and N. El-Mabrouk.
    Journal of Computational Biology , Vol. 15, No.8, pp 1043-1062, 2008.
  • Gene Maps Linearization using Genomic Rearrangement Distances.
    G. Blin, E. Blais, D. Hermelin, P. Guillon, M. Blanchette and N. El-Mabrouk.
    Journal of Computational Biology, Vol. 14, No. 4, pp.394-407, 2007.
  • Duplication and Inversion History of a Tandemly Repeated Genes Family.
    M. Lajoie, D. Bertrand, N. El-Mabrouk and O. Gascuel.
    Journal of Computational Biology, Vol. 14, Issue 4, pp. 462-478, 2007.
  • Deriving Haplotypes through Recombination and Gene Conversion.
    N. El-Mabrouk.
    Journal of Bioinformatics and Computational Biology, Vol. 2, No. 2, pp. 241-256, June 2004.
  • Detection and Validation of Single Gene Inversions .
    J.F. Lefebvre and N. El-Mabrouk, E. Tillier and D. Sankoff.
    Bioinformatics, Vol. 19, Suppl. 1, special issue, 11th International Conference on Intelligent Systems for Molecular Biology (ISMB), pp 190-196, 2003.
  • Approximate Matching of Secondary Structures - Extended Abstract.
    N. El-Mabrouk and M. Raffinot.
    Proceedings of the sixth annual international conference on computational molecular biology (RECOMB02), pages 156-164, April 2002.
    The algorithm contains a flaw. For the complete and corrected version, consult our paper in Journal of Bioinformatics and Computational Biology above.
  • Computational Methods for Genome Comparison and Applications.
    D. Sankoff, N. El-Mabrouk.
    Current Topics in Computational Biology, Chapter 10, Computational Molecular Biology Series, MIT Press, 2001.
  • N. El-Mabrouk. Recovery of ancestral tetraploids. Comparative Genomics: Empirical and Analytical Approaches to Gene Order Dynamics, Map alignment and the Evolution of Gene Families. Computational Biology Series. Kluwer Academic Publishers. Vol 1. pp. 465-477, 2000.
  • D. Sankoff and N. El-Mabrouk. Duplication, rearrangement and reconciliation. Comparative Genomics: Empirical and Analytical Approaches to Gene Order Dynamics, Map alignment and the Evolution of Gene Families. Computational Biology Series. Kluwer Academic Publishers. Vol. 1, pp. 537-550, 2000.
  • N. El-Mabrouk and D. Bryant and D. Sankoff. Reconstructing the Pre-Doubling Genome. Third annual international conference on computational molecular biology (RECOMB99), to appear in the conference proceedings, ACM press. Lyon, France, April 1999.
  • N. El-Mabrouk and J. Nadeau and D. Sankoff. Genome Halving. In M. Farach editor, Lecture Notes in Computer Science, volume 1448 of CPM, 9th annual symposium, pages 235-250. Piscataway, New-Jersey, USA, July 1998.
  • N. El-Mabrouk and F. Lisacek. Very fast identification of RNA motifs in genomic DNA. Application to tRNA search in the yeast genome. Journal of Molecular Biology, 264:46-55, November 1996.